This personal project served as a practice project and a prototype for skeletal-muscle-tissue animations. What made this workflow possible in Blender? I like to use Houdini as a source of inspiration when it comes to complex workflows. This is what I did in this case, getting inspired by Houdini Muscles. Knowing that physically accurate muscles can be simulated by Vellum, one could simply create a similar workflow in Blender:
Blender Muscle Physics Breakdown
PureRef References